Headline: “Engine B” Leverages the Biophysics of Nucleosomal Cleavage to Track the Structural Footprints of Tumors.

Pushing the boundaries of physical biology, KCCIRC’s Frag-Sure pipeline features Engine B, a microscopic precision discriminator that operates on the biophysics of endonucleolytic cleavage. Because tumor cfDNA undergoes rapid necrosis and aberrant cleavage, the engine isolates DNA fragments systematically truncated to less than 150bp, distinguishing them from the standard 166bp fragments shed by healthy apoptotic tissue.