Headline: “Engine A” Deploys Pseudo-LOESS GC Normalization to Identify Pathological Aneuploidy.

To establish a computational “noise floor” for a healthy genome, KCCIRC’s Frag-Sure “Engine A” partitions the genome into 500kb non-overlapping segments and applies pseudo-LOESS GC normalization. The system then utilizes a highly robust Median Absolute Deviation (MAD) statistic to quantify macroscopic chromosomal chaos and model the patient’s total Tumor Fraction (TF).